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Senior Translational ScientistRef: DT24031

Salary:€115000 - €130000 per annum

Added:14 Mar 2019

Region: Europe

Sector: Pharmaceutical

Sub Sector: Clinical Research

DESCRIPTION: The Pharmacology & Screening team is dedicated to accelerating the development of new therapies for cancer by leveraging the knowledge around our drug candidates. Your main responsibilities: *Works in matrix organization in close collaboration with other Translational Medicine functions (DMPK, Preclinical Safety and Diagnostics/Personalized Medicine) to characterize the pharmacological properties of our drug candidates: *Represents the Translational Pharmacology function in the Translational Medicine Project Teams; *May represent the Translational Medicine function in the global Project Teams and lead a Translational Medicine Project Team (core team member). *Manages laboratory-to-human research in Contract Research Organizations: designs, monitors, and reports the primary and secondary pharmacology studies performed: *In vitro/in vivo pharmacology compounds selection and profiling, including off target characterization *Proof of concept in vivo studies - PK/PD *Mechanism of action studies *Identification, method development/validation of clinical pharmacodynamic (PDy) biomarkers *As clinical study team member *Defines and manages the clinical translational PDy analyses (incl. blood and tissue biomarkers), data analyses and reporting according to GCPs and GCLPs *Supports and advises the Clinical Research and Development team *Contributes to the preparation of the pharmacology regulatory documentation (IDB, summaries for IND and IMPD, briefing documentation) *May participate in interactions with Health Authorities. *Participates in external scientific communications (publications, poster and oral presentations). Your profile: *PhD in relevant expertise area or equivalent in biomedical engineering *More than 5 years demonstrated experience in Translational Pharmacology Research and drug development in oncology projects *Experience in the pharma industry a strong asset *In-depth knowledge in translational research in personalized oncology and basic knowledge of related disciplines including histopathology, bioanalytics, pharmacokinetics and PK/PD *Knowledge of GCP, GCLP and ICH guidelines; animal welfare regulations; and cancer drug development and regulations *Very good IT and analytical skills incl. advanced graphical explorations (R statistical software and image analysis, a plus) *Excellent communication and presentation skills (oral and written) *Fluent in English *Project management experience *Excellent team working skills *An international and highly dynamic environment. *The opportunity to join a successful company, at the forefront of the most advanced scientific developments in the industry. *The possibility to be in a company in which innovation, people and entrepreneurship are the fundamentals of its success.

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